Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing
Sustained pacemaker function is a challenge in biological pacemaker engineering.Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation.We studied whether lentivirally transduced CMPCs that express the pacemaker current If (encoded by HCN4) can be used as functional gene delivery vehicle in b